免疫炎症研发资深科学家/副总监
上海齐鲁制药研究中心有限公司
- 公司规模:10000人以上
- 公司性质:民营公司
- 公司行业:制药/生物工程
职位信息
- 发布日期:2020-10-20
- 工作地点:上海-浦东新区
- 招聘人数:2人
- 工作经验:8-9年经验
- 学历要求:博士
- 职位月薪:3-4.5万/月
- 职位类别:生物工程/生物制药
职位描述
岗位职责:
1、带领生物学团队致力于免疫/炎症创新药物的研发,按时交付高质量的临床候选药物;
2、研究剖析新药的作用机制,完成成药性研究,支持IND提交;
3、制定并实施战略,开发用于调节B细胞,T细胞和先天免疫细胞功能的新疗法,发现新靶点;
4、在现有模型的基础上,建立新颖的体内和体外筛选平台,并利用这些平台来识别和表征新药在B细胞,T细胞和先天免疫细胞生物学领域的功能和治疗潜力;
5、申请专利并在学术期刊和会议上发表创新成果;
6、通过指导,培训或激励团队成员来展示科学家团队精神。
任职资格:
1、博士学历,免疫学,药理学,细胞生物学或相关专业,至少8年相关工作经验,有工业界研发经验优先;
2、在炎症和/或自身免疫性疾病领域具有丰富的科学和技术知识,并对类风湿性关节炎,狼疮,牛皮癣或纤维化等疾病机制有较深的了解;
3、熟练掌握炎症和自身免疫性疾病领域的科学文献,善于将已公布数据的实际应用经验应用到在研的项目中;
4、具备炎症/自身免疫性疾病动物模型的知识和经验;
5、良好的书面和口头沟通技巧,能够进行有效的演示和数据分析;
6、具有强大的解决问题的能力,能够有效地应对变化,可以快速适应和解决冲突,并且在没有完整信息的情况下调整方向和行动;处理复杂的问题时,能提供创造性的解决方案;
7、公开,诚实,公平 ,良好的沟通能力和团队合作精神,影响和激励团队中的其他成员实现工作目标。
Position Summary:
The Department of Immunology/Inflammation at Qilu Pharmaceutic have opportunities for highly motivated and talented research scientists to join a group focused on T cell and B cell biology. The candidate will utilize state-of-the-art in vitro and in vivo approaches to discover and validate new drug targets. A primary focus will be on measurement of T cell (Th1, Th2, Th17, and Treg) and B cell responses ex vivo using cytokine induction and proliferation assays, intercellular cytokine staining, and flow cytometric analysis. Isolation of immune cell subsets from lymphoid and non-lymphoid tissues will also be performed.
Position requirements:
? Possesses a working knowledge of mouse models of autoimmune disease and possess an understanding of how to apply knock-out/knock-in technologies to better understand disease pathology.
? Possesses an excellent record of accomplishment of independent research with publications in high impact, peer-reviewed journals.
? Demonstrates ability to independently design, execute, and interpret experiments, and should be able to manage and prioritize a number of different project responsibilities within the scope of the group.
? Possesses a keen scientific interest, strong written and oral communication skills, and the desire to work effectively in a fast paced, collaborative environment are essential.
? A rigorous and creative scientist who can carry out basic research in pursuit of innovative treatments for autoimmune and chronic inflammatory diseases.
? Possesses hands-on, in vivo research experience in models of T cell dependent autoimmunity and inflammation.
? Well-read in the field of T cell immunology, particularly as it relates to autoimmunity.
? A strong desire to publish in high impact, peer reviewed journals.
? Demonstrated experience in the development of in vitro cellular assays to assess lymphocyte and myeloid cell activities.
? Strong hands-on skills in immunological, biochemical, and molecular techniques including cell culture, use of primary tissues and cells, multi-parameter flow cytometry (both intracellular and cell surface markers), quantification of mRNA (qPCR), Transcriptomics and Single-cell RNA sequencing, quantification of protein expression, immunohistochemistry, and western blotting.
Qualifications:
Education: Ph.D. in Immunology or related field
Special Skills/Abilities:
? Highly motivated, innovative, creative, organized and able to independently perform and plan experiments
? A keen scientific interest, strong written and oral communication skills, and the desire to work effectively in a fast paced, collaborative environment.
? Extensive knowledge in the biology of different immune cells such as T cells, B cells and macrophages
Job Complexity: Candidates should be able to manage and prioritize a number of different project responsibilities.
职能类别:生物工程/生物制药
公司介绍
上海齐鲁创新药研发中心坐落于上海张江,是齐鲁创新药物研究、人才培养、国际合作交流的综合平台。负责齐鲁大小分子创新药研发的整体规划、创新药项目的研发、以及与海外创新药研发公司(美国西雅图、旧金山、波士顿研发中心)的协同。
行业荣誉:
中国企业集团竞争力500强
中国医药工业百强企业 第8位
中国制药工业百强企业 TOP10榜
中国化学制药工业企业综合实力百强 第2位
中国医药研发产品线***工业企业 第2位
中国医药十大最具影响力企业
十大最具成长力制药企业
中国医药三十年行业贡献奖
中国医药工业最具投资价值 TOP10榜
中国医药工业 50强
中国100家***医药工业企业
医药企业十优国际化先导企业
研发荣誉:
***企业技术中心
中国医药企业创新力二十强
中国医药研发产品线***工业企业
十大中国最具创新力医药企业
国内***研发产品线十佳工业企业
哺乳动物细胞高效表达国家工程实验室
联系方式
- 公司地址:浦东新区李冰路576号创想园2号楼 (邮编:200201)