上海招聘

职位描述：
We are looking for a dynamic individual to join our computational chemistry group. The successful candidate must have the drive and enthusiasm to handle multiple projects simultaneously. He/She must also represent BioDuro to multiple clients and be able to interact across disciplines.
The successful candidate will have a solid theoretical and practical knowledge of molecular modeling, cheminformatics, virtual screening, QSAR, and data mining. A keen interest in hypothesis-driven drug discovery, strong problem solving skills, and the ability to work in a team environment by engaging with cross-functional scientists are key elements of the role.
The ideal candidate will have a proven track record of applying computational chemistry techniques to advance small-molecule drug discovery programs.The position will be based at BioDuro's Shanghai facilities.


Responsibilities:
? Work closely with clients, such as major international pharmaceutical and biotech companies on their drug discovery programs
? Responsible for providing computational chemistry support to structure-, ligand- and fragment-based drug discovery projects as well as virtual screening efforts
? Utilize software for in silico prediction of ADME, biology, and safety properties
? Develop QSAR model for data analysis
? Work collaboratively with chemists and project teams to design compounds with improved potency, selectivity, functional activity and/or ADME properties
? Support various database and software systems to collect, disseminate, and analyze all pre-clinical small molecule discovery data to our internal and external scientists

Requirements:

? M.S. (or above) in Computational Chemistry, Organic Chemistry or a related discipline
? At least two years of hands-on experience in two or more of the following areas: structure-based drug design including docking, homology modeling, molecular dynamics simulation, free energy calculation; ligand-based drug design including pharmacophore modeling, QSAR, 3D-QSAR, pharmacophore- or shape-based database searching, combinatorial and fragment library design, focused library construction, R-group decomposition, pairwise matching, cliff analysis
? Familiarity with state-of-the-art modeling and cheminformatics tools such as Maestro, MOE, Gold, JChem, Vortex, Spotfire, Knime, etc.
? Strong problem solving skills and the ability to work in a fast-paced environment
? Preferred Requirements:
? Pharma or biotech experience with a focus on computational chemistry and strong understanding of drug design principles
? Solid understanding of medicinal chemistry concepts and demonstrated success in addressing medicinal chemistry design challenges
? Familiarity with common programming languages such as Perl, Java and C++, as well as functional familiarity with web technologies
? Fluency in written and spoken English 举报 分享

关于BioDuro

保诺科技是一家领先的生命科学研发公司，专业为生物制药客户提供从靶标识别到III期的一体化药物研发服务。
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